Date(s) - 09/24/2021
3:05 pm - 4:05 pm
Therapeutics to Enhance Wound Healing and Tissue Repair
Jordan R. Yaron, Ph.D.
Assistant Research Professor in the Rege Bioengineering Lab, Arizona State University (SEMTE)
Date: Friday, September 24, 2021
Time: 3:05 p.m.
Location: SCOB 228
The reparative biological response to injury is a complex and coordinated process involving the orchestration of many types of cellular systems through a series of continuous, overlapping temporal phases. The impairment of any stage of healing can lead to chronic wounds and tissue dysfunction, resulting in dramatically increased morbidity and mortality. For example, chronic dermal wounds are a major complication of diabetes mellitus (DM) and is the primary cause of limb amputation, with DM patients subject to more than a 15% lifetime risk of limb loss. Despite growing knowledge around the biological repair process, there is an urgent and unmet need for new treatments to enhance tissue repair. In this talk, I will discuss two approaches under exploration at ASU to enhance wound healing and tissue repair. In the first approach, virus-derived immune modulators – originally evolved for the infection process – are repurposed as therapeutic biologics to treat dermal wounds, spinal cord injury, liver injury and lupus-associated lung hemorrhage by modulation of the immune response. In the second approach, naturally-produced silk is bioengineered into novel wound dressings and combined with endogenous and engineered wound modulators to target and manipulate the temporal phases of wound repair. Together, these vignettes will introduce attendees to the innovative ways ASU is exploring how to learn from the biological world outside our door to create use-inspired solutions for major and growing medical problems.
Jordan R. Yaron is an Assistant Research Professor in the Rege Bioengineering Lab at Arizona State University’s School for Engineering of Matter, Transport and Energy (SEMTE). Dr. Yaron is a molecular and cell biologist with more than 12 years of expertise in mechanisms of innate immunology and inflammation, described in more than 30 peer-reviewed publications. His research focuses on understanding the physiological and pathological response to tissue injury and the translation of these mechanisms to develop approaches for therapeutic modulation of healing. Prior to joining SEMTE, he completed a postdoctoral fellowship at Mayo Clinic with Vijay Singh, M.D. studying the role of dysregulated lipolysis and dietary fat composition in the adverse outcomes of acute pancreatitis and a second postdoctoral fellowship at the ASU Biodesign Institute with Alexandra Lucas, M.D. developing Myxoma virus-derived therapeutic immune modulators for dermal wound healing, spinal cord injury, liver ischemia-reperfusion injury, lupus-associated lung heomrrhage and lethal gammaherpesvirus vasculitis. Dr. Yaron received his Ph.D. in Biological Design at ASU in 2015 with Deirdre Meldrum, Ph.D. for his work describing the regulation of the NLRP3 inflammasome pathway by the flux of potassium and calcium ions across macrophage membranes. Dr. Yaron has editorial roles in the journals Pharmaceutics and Vaccines, is a member of the American Society for Cell Biology and the Society for Leukocyte Biology and holds leadership roles in the Arizona Imaging and Microanalysis Society and Wound Healing Society