Date(s) - 09/03/2021
3:05 pm - 4:05 pm
Biomimetic Advanced Cell Culture Platforms for Drug Screening and Tissue Engineering Applications
Jyothi Menon, Ph.D.
Assistant Professor of Biomedical and Pharmaceutical Sciences, and Chemical Engineering, University of Rhode Island
Date: Friday, September 3, 2021
Time: 3:05 p.m.
Location: SCOB 228
Cell culture is an essential tool in biomedical research to improve our understanding of cellular and molecular processes, and to test cellular responses to new therapies. However, conventionally used two-dimensional cell cultures grown on tissue culture plastics has limited physiological relevance. This is one of the reasons for the high attrition rates of new drug molecules during clinical trials despite showing promising results in the laboratory. Compelling evidence in recent years suggest that three-dimensional (3D) and complex cell cultures can provide valuable insights into cell-cell interactions and responses to new pharmaceutical compounds. Both scaffold-based and scaffold-free techniques have been explored to develop and study these complex cultures. In this talk, I will discuss our research on the development of porous polymeric microparticles as scaffolds for lung tumor culture in vitro. I will also present our recent work on thermoresponsive microwell arrays and photoinks for the high-throughput culture and stress-free isolation of 3D cell aggregates (spheroids), which is an improvement over the comparatively static platforms used for advanced cell culture today.
Dr. Jyothi Menon is an Assistant Professor of Biomedical and Pharmaceutical Sciences, and Chemical Engineering at the University of Rhode Island. She received her M.S. and Ph.D. degrees in Biomedical Engineering from the University of Texas (UT) Southwestern Medical Center, Dallas and UT Arlington joint program in 2010 and 2014 respectively. She then joined the University of Oxford, UK, where she worked as an Engineering and Physical Sciences Research Council (EPSRC)-funded postdoctoral researcher as part of the multidisciplinary team at the Oxford Centre for Drug Delivery Devices (OXCD3). In 2017, she joined the University of Rhode Island as an Assistant Professor, where her current research focus is on developing (i) inhalable nanoparticle formulations for the treatment of chronic pulmonary diseases, and (ii) tissue engineered disease models for drug screening applications, and to evaluate cellular responses to toxins.