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Engineering | School of Biological and Health Systems Engineering

SBHSE Assistant Professor Dr. Barbara Smith’s development of patch clamp electrophysiology recently appeared in a case study by Scientifica. The lab of Dr. Barbara Smith is the first to incorporate a real-time, photoacoustic feedback system into traditional micropipette electrodes to target, stimulate, and record neurons deep within the living mammalian brain using the PatchStar micromanipulator. This novel technology serves as the foundation of a new scalable and automated approach to measure and control neuronal signals deep in the living brain with spatial resolution and genetic specificity. This powerful method will enable investigators to better characterize and understand complex neural interactions, improving our fundamental understanding of critical changes in neurological function.

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